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In vehicle racing , nitrous oxide often referred to as just " nitrous " allows the engine to burn more fuel by providing more oxygen than air alone, resulting in a more powerful combustion. Therefore, it often is mixed with another fuel that is easier to deflagrate. Nitrous oxide is a strong oxidant, roughly equivalent to hydrogen peroxide, and much stronger than oxygen gas.

Sometimes nitrous oxide is injected into or prior to the intake manifold, whereas other systems directly inject, right before the cylinder direct port injection to increase power.

Originally meant to provide the Luftwaffe standard aircraft with superior high-altitude performance, technological considerations limited its use to extremely high altitudes. Accordingly, it was only used by specialized planes such as high-altitude reconnaissance aircraft , high-speed bombers , and high-altitude interceptor aircraft.

It sometimes could be found on Luftwaffe aircraft also fitted with another engine-boost system, MW 50 , a form of water injection for aviation engines that used methanol for its boost capabilities. One of the major problems of using nitrous oxide in a reciprocating engine is that it can produce enough power to damage or destroy the engine. Very large power increases are possible, and if the mechanical structure of the engine is not properly reinforced, the engine may be severely damaged, or destroyed, during this kind of operation.

It is very important with nitrous oxide augmentation of petrol engines to maintain proper operating temperatures and fuel levels to prevent "pre-ignition", [10] or "detonation" sometimes referred to as "knock".

Most problems that are associated with nitrous oxide do not come from mechanical failure due to the power increases. Since nitrous oxide allows a much denser charge into the cylinder, it dramatically increases cylinder pressures. The increased pressure and temperature can cause problems such as melting the piston or valves. It also may crack or warp the piston or head and cause pre-ignition due to uneven heating.

Automotive-grade liquid nitrous oxide differs slightly from medical-grade nitrous oxide. A small amount of sulfur dioxide SO 2 is added to prevent substance abuse. The gas is approved for use as a food additive also known as E , specifically as an aerosol spray propellant. Its most common uses in this context are in aerosol whipped cream canisters, cooking sprays , and as an inert gas used to displace oxygen in order to inhibit bacterial growth when filling packages of potato chips and other similar snack foods.

The gas is extremely soluble in fatty compounds. In aerosol whipped cream, it is dissolved in the fatty cream until it leaves the can, when it becomes gaseous and thus creates foam. Used in this way, it produces whipped cream four times the volume of the liquid, whereas whipping air into cream only produces twice the volume. If air were used as a propellant, oxygen would accelerate rancidification of the butterfat, but nitrous oxide inhibits such degradation.

Carbon dioxide cannot be used for whipped cream because it is acidic in water, which would curdle the cream and give it a seltzer-like "sparkling" sensation. The whipped cream produced with nitrous oxide is unstable, however, and will return to a more liquid state within half an hour to one hour. During December , some manufacturers reported a shortage of aerosol whipped creams in the United States due to an explosion at the Air Liquide nitrous oxide facility in Florida in late August.

With a major facility offline, the disruption caused a shortage resulting in the company diverting the supply of nitrous oxide to medical clients rather than to food manufacturing. The shortage came during the Christmas and holiday season when canned whipped cream use is normally at its highest. Similarly, cooking spray , which is made from various types of oils combined with lecithin an emulsifier , may use nitrous oxide as a propellant. Other propellants used in cooking spray include food-grade alcohol and propane.

Nitrous oxide has been used in dentistry and surgery, as an anaesthetic and analgesic, since In the early days, the gas was administered through simple inhalers consisting of a breathing bag made of rubber cloth. Nitrous oxide is a weak general anaesthetic , and so is generally not used alone in general anaesthesia, but used as a carrier gas mixed with oxygen for more powerful general anaesthetic drugs such as sevoflurane or desflurane.

The use of nitrous oxide in anaesthesia, however, can increase the risk of postoperative nausea and vomiting. The patient is kept conscious throughout the procedure, and retains adequate mental faculties to respond to questions and instructions from the dentist. Inhalation of nitrous oxide is used frequently to relieve pain associated with childbirth , trauma , oral surgery , and acute coronary syndrome includes heart attacks.

Its use during labour has been shown to be a safe and effective aid for birthing women. In Britain and Canada, Entonox and Nitronox are used commonly by ambulance crews including unregistered practitioners as a rapid and highly effective analgesic gas.

The rapid reversibility of its effect would also prevent it from precluding diagnosis. Starting already in the nineteenth century, widespread availability of the gas for medical and culinary purposes allowed the recreational use to expand greatly, throughout the world.

In the United Kingdom, as of , nitrous oxide was estimated to be used by almost half a million young people at nightspots, festivals, and parties. The major safety hazards of nitrous oxide come from the fact that it is a compressed liquefied gas, an asphyxiation risk, and a dissociative anaesthetic. While relatively non-toxic, nitrous oxide has a number of recognized ill effects on human health, whether through breathing it in or by contact of the liquid with skin or eyes.

Nitrous oxide is a significant occupational hazard for surgeons, dentists, and nurses. Because nitrous oxide is minimally metabolised in humans with a rate of 0. Where nitrous oxide is administered, a continuous-flow fresh-air ventilation system or N 2 O scavenger system is used to prevent a waste-gas buildup. The National Institute for Occupational Safety and Health recommends that workers' exposure to nitrous oxide should be controlled during the administration of anaesthetic gas in medical, dental, and veterinary operators.

Exposure to nitrous oxide causes short-term decreases in mental performance, audiovisual ability, and manual dexterity. Like other NMDA antagonists , N 2 O was suggested to produce neurotoxicity in the form of Olney's lesions in rodents upon prolonged several hour exposure. This is especially true of non-medical formulations such as whipped-cream chargers also known as "whippets" or "nangs" , [34] which never contain oxygen, since oxygen makes cream rancid.

Additionally, nitrous oxide depletes vitamin B 12 levels. This can cause serious neurotoxicity if the user has preexisting vitamin B 12 deficiency. If pure nitrous oxide is inhaled without oxygen mixed in, this can eventually lead to oxygen deprivation resulting in loss of blood pressure, fainting and even heart attacks. This can occur if the user inhales large quantities continuously, as with a strap-on mask connected to a gas canister.

It can also happen if the user engages in excessive breath-holding or uses any other inhalation system that cuts off their supply of fresh air. Long-term exposure to nitrous oxide may cause vitamin B 12 deficiency. It inactivates the cobalamin form of vitamin B 12 by oxidation. Symptoms of vitamin B 12 deficiency , including sensory neuropathy , myelopathy , and encephalopathy , may occur within days or weeks of exposure to nitrous oxide anaesthesia in people with subclinical vitamin B 12 deficiency.

Symptoms are treated with high doses of vitamin B 12 , but recovery can be slow and incomplete. People with normal vitamin B 12 levels have stores to make the effects of nitrous oxide insignificant, unless exposure is repeated and prolonged nitrous oxide abuse. Vitamin B 12 levels should be checked in people with risk factors for vitamin B 12 deficiency prior to using nitrous oxide anaesthesia. Several experimental studies in rats indicate that chronic exposure of pregnant females to nitrous oxide may have adverse effects on the developing fetus.

The pressure curve is thus unusually sensitive to temperature. There also have been incidents where nitrous oxide decomposition in plumbing has led to the explosion of large tanks.

The pharmacological mechanism of action of N 2 O in medicine is not fully known. However, it has been shown to directly modulate a broad range of ligand-gated ion channels , and this likely plays a major role in many of its effects. The effects of inhaling sub-anaesthetic doses of Nitrous Oxide have been known to vary, based on several factors, including settings and individual differences, [51] [52] however, from his discussion, Jay [26] suggests that it has been reliably known to induce the following states and sensations:.

A minority of users also will present with uncontrolled vocalisations and muscular spasms. These effects generally disappear minutes after removal of the nitrous oxide source. In rats, N 2 O stimulates the mesolimbic reward pathway via inducing dopamine release and activating dopaminergic neurons in the ventral tegmental area and nucleus accumbens , presumably through antagonisation of NMDA receptors localised in the system. It is remarkable, however, that in mice, N 2 O blocks amphetamine -induced carrier-mediated dopamine release in the nucleus accumbens and behavioural sensitisation , abolishes the conditioned place preference CPP of cocaine and morphine , and does not produce reinforcing or aversive effects of its own.

In behavioural tests of anxiety , a low dose of N 2 O is an effective anxiolytic , and this anti-anxiety effect is associated with enhanced activity of GABA A receptors, as it is partially reversed by benzodiazepine receptor antagonists. Mirroring this, animals that have developed tolerance to the anxiolytic effects of benzodiazepines are partially tolerant to N 2 O.

The analgesic effects of N 2 O are linked to the interaction between the endogenous opioid system and the descending noradrenergic system.

When animals are given morphine chronically, they develop tolerance to its pain-killing effects, and this also renders the animals tolerant to the analgesic effects of N 2 O. Nitrous oxide supports combustion by releasing the dipolar bonded oxygen radical, [Name?

N 2 O is inert at room temperature and has few reactions. At elevated temperatures, its reactivity increases. The above reaction is the route adopted by the commercial chemical industry to produce azide salts, which are used as detonators.

The gas was first synthesised in by English natural philosopher and chemist Joseph Priestley , who called it phlogisticated nitrous air see phlogiston [72] or inflammable nitrous air. The first important use of nitrous oxide was made possible by Thomas Beddoes and James Watt , who worked together to publish the book Considerations on the Medical Use and on the Production of Factitious Airs This book was important for two reasons.

First, James Watt had invented a novel machine to produce "Factitious Airs" i. Second, the book also presented the new medical theories by Thomas Beddoes, that tuberculosis and other lung diseases could be treated by inhalation of "Factitious Airs".

The machine to produce "Factitious Airs" had three parts: The breathing apparatus consisted of one of the portable air bags connected with a tube to a mouthpiece. With this new equipment being engineered and produced by , the way was paved for clinical trials , [ clarification needed ] which began in when Thomas Beddoes established the " Pneumatic Institution for Relieving Diseases by Medical Airs" in Hotwells Bristol.

In the basement of the building, a large-scale machine was producing the gases under the supervision of a young Humphry Davy , who was encouraged to experiment with new gases for patients to inhale. Researches, Chemical and Philosophical In that publication, Davy notes the analgesic effect of nitrous oxide at page and its potential to be used for surgical operations at page Despite Davy's discovery that inhalation of nitrous oxide could relieve a conscious person from pain, another 44 years elapsed before doctors attempted to use it for anaesthesia.

The use of nitrous oxide as a recreational drug at "laughing gas parties", primarily arranged for the British upper class , became an immediate success beginning in While the effects of the gas generally make the user appear stuporous, dreamy, and sedated, some people also "get the giggles" in a state of euphoria, and frequently erupt in laughter. One of the earliest commercial producers in the U. The first time nitrous oxide was used as an anaesthetic drug in the treatment of a patient was when dentist Horace Wells , with assistance by Gardner Quincy Colton and John Mankey Riggs , demonstrated insensitivity to pain from a dental extraction on 11 December The reason for this was most likely that Wells, in January at his first public demonstration to the medical faculty in Boston, had been partly unsuccessful, leaving his colleagues doubtful regarding its efficacy and safety.

Nitrous oxide was not found to be a strong enough anaesthetic for use in major surgery in hospital settings, however. Instead, diethyl ether , being a stronger and more potent anaesthetic, was demonstrated and accepted for use in October , along with chloroform in Clover's gas-ether inhaler was designed to supply the patient with nitrous oxide and ether at the same time, with the exact mixture being controlled by the operator of the device.

It remained in use by many hospitals until the s. Colton's popularization of nitrous oxide led to its adoption by a number of less than reputable quacksalvers , who touted it as a cure for consumption , scrofula , catarrh , and other diseases of the blood, throat, and lungs. Nitrous oxide treatment was administered and licensed as a patent medicine by the likes of C.

Nitrous oxide is prepared on an industrial scale by careful heating of ammonium nitrate at about C, which decomposes into nitrous oxide and water vapour. The addition of various phosphate salts favours formation of a purer gas at slightly lower temperatures.

This reaction may be difficult to control, resulting in detonation. The decomposition of ammonium nitrate is also a common laboratory method for preparing the gas. Equivalently, it can be obtained by heating a mixture of sodium nitrate and ammonium sulfate: Another method involves the reaction of urea, nitric acid, and sulfuric acid: Direct oxidation of ammonia with a manganese dioxide - bismuth oxide catalyst has been reported: Hydroxylammonium chloride reacts with sodium nitrite to give nitrous oxide.

If the nitrite is added to the hydroxylamine solution, the only remaining by-product is salt water. If the hydroxylamine solution is added to the nitrite solution nitrite is in excess , however, then toxic higher oxides of nitrogen also are formed:.

Nitrous oxide is a minor component of Earth's atmosphere, currently with a concentration of about 0. As of , it was estimated that about Most of the N 2 O emitted into the atmosphere, from natural and anthropogenic sources, is produced by microorganisms such as bacteria and fungi in soils and oceans.

These activities stimulate naturally-occurring bacteria to produce more nitrous oxide. Among industrial emissions, the production of nitric acid and adipic acid are the largest sources of nitrous oxide emissions. The adipic acid emissions specifically arise from the degradation of the nitrolic acid intermediate derived from nitration of cyclohexanone. Natural processes that generate nitrous oxide may be classified as nitrification and denitrification.

These processes are affected by soil chemical and physical properties such as the availability of mineral nitrogen and organic matter, acidity, and soil type; as well as climate-related factors such as soil temperature and water content e.

The emission of the gas to the atmosphere is limited greatly by its consumption inside the cells, by a process catalyzed by the enzyme nitrous oxide reductase. Nitrous oxide has a significant global warming potential as greenhouse gas. A study by Nobel Laureate Paul Crutzen suggests that the amount of nitrous oxide release attributable to agricultural nitrate fertilizers has been seriously underestimated, most of which presumably, would come under soil and oceanic release in the Environmental Protection Agency data.

Nitrous oxide also has been implicated in thinning of the ozone layer. A new study suggests that N 2 O emission currently is the single most important ozone-depleting substance ODS emission and is expected to remain the largest throughout the twenty-first century. In the United States , possession of nitrous oxide is legal under federal law and is not subject to DEA purview.

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