Haldol (Haloperidol Injection): Side Effects, Interactions, Warning, Dosage & Uses

haloperidol (Haldol)

haldol 20 mg im

Decreased sensation of thirst due to central inhibition may lead to dehydration, hemoconcentration and reduced pulmonary ventilation; a number of cases of bronchopneumonia, some fatal, reported; if signs and symptoms appear, especially in the elderly, institute remedial therapy promptly. Do not start a new medication without telling your doctor. Haloperidol may result in a movement disorder known as tardive dyskinesia which may be permanent. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS. Overdose symptoms may include extreme drowsiness, feeling like you might pass out, tremors, and uncontrolled muscle movements in your eyes, tongue, jaw, or neck. In some cases, this condition may be permanent. Haloperidol is not for use in psychotic conditions related to dementia.

Side Effects

There is considerable variation from patient to patient in the amount of medication required for treatment. Schizophrenia, Psychosis PO Moderate disease, 0. Tell your doctor right away if any of these rare but very serious side effects occur: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Controlled trials to establish the safety and effectiveness of intramuscular administration in children have not been conducted. Haloperidol may reduce the chance of relapse, but, at present there is only very limited data supporting this finding.

Haloperidol acts on these receptors: The drug is well and rapidly absorbed with a high bioavailability when injected intramuscularly. The T max is 20 minutes in healthy individuals and The plasma concentrations of haloperidol decanoate reach a peak at about six days after the injection, falling thereafter, with an approximate half-life of three weeks.

The apparent volume of distribution is between 9. If haloperidol is given as a slow IV infusion, the onset of action is slowed, and the duration of action is prolonged. Plasma levels of four to 25 micrograms per liter are required for therapeutic action. The determination of plasma levels can be used to calculate dose adjustments and to check compliance, particularly in long-term patients.

Plasma levels in excess of the therapeutic range may lead to a higher incidence of side effects or even pose the risk of haloperidol intoxication. The concentration of haloperidol in brain tissue is about fold higher compared to blood levels. It is slowly eliminated from brain tissue, [51] which may explain the slow disappearance of side effects when the medication is stopped.

Haloperidol is heavily protein bound in human plasma, with a free fraction of only 7. The greatest proportion of the hepatic clearance is by glucuronidation, followed by reduction and CYP-mediated oxidation, primarily by CYP3A4.

Haloperidol was discovered by Paul Janssen. Haloperidol was approved by the U. Haloperidol is also used on many different kinds of animals. It appears to be particularly successful when given to birds, e. From Wikipedia, the free encyclopedia. C Risk not ruled out. S4 Prescription only CA: Aspen Pharma Pty Ltd. Archived from the original on 14 March Retrieved 29 May Archived from the original on Retrieved 2 January The New England Journal of Medicine. Archived from the original on 8 April The evolution of drug discovery: Archived PDF from the original on 13 December Retrieved 8 December Health care needs assessment: Seminars in general adult psychiatry 2.

Clinical handbook of schizophrenia Pbk. James; Underwood, Ned A. American Journal of Therapeutics. James; Eighan, Michael S. The Journal of Clinical Pharmacology. The Complete Drug Reference. The Medical clinics of North America. Journal of Psychiatric Practice. Treatment of behavioral emergencies". Postgraduate Medicine Spec No: A Summary of the Expert Consensus Guidelines". Methods, Commentary, and Summary".

Cochrane Database of Systematic Reviews. Retrieved 21 April American Academy of Hospice and Palliative Medicine. Archived from the original on 1 September Retrieved 1 August Journal of Pain and Symptom Management. Journal of Palliative Medicine. Janssen; [cited Sep 29].

Archived PDF from the original on Current Opinion in Psychiatry. American Journal of Health-System Pharmacy. A report of 2 cases". South African medical journal. The Journal of Pharmacology and Experimental Therapeutics.

A novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity". The Journal of Clinical Psychiatry. Naunyn-Schmiedeberg's Archives of Pharmacology. The American Journal of Psychiatry. Clinical impact of persistence and region-specific distribution".

European Archives of Psychiatry and Clinical Neuroscience. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking haloperidol, do not stop taking it without your doctor's advice. Haloperidol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take haloperidol Haldol? Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Taking too much of this medication can cause a serious heart rhythm disorder or sudden death. Never take more than your prescribed dose. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using haloperidol suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using haloperidol. What happens if I miss a dose Haldol? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose Haldol? Seek emergency medical attention or call the Poison Help line at An overdose of haloperidol can be fatal. Overdose symptoms may include extreme drowsiness, feeling like you might pass out, tremors, and uncontrolled muscle movements in your eyes, tongue, jaw, or neck.

What should I avoid while taking haloperidol Haldol? Avoid becoming overheated or dehydrated during exercise and in hot weather. You may be more prone to heat stroke while you are taking haloperidol.

What other drugs will affect haloperidol Haldol? Before using haloperidol, tell your doctor if you regularly use other medicines that make you sleepy such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety.

They can add to sleepiness caused by haloperidol. This list is not complete and other drugs may interact with haloperidol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Where can I get more information? Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.

Iamges: haldol 20 mg im

haldol 20 mg im

Tier Description 1 This drug is available at the lowest co-pay. Psychosis prochlorperazine , Compazine , haloperidol , Haldol , chlorpromazine , perphenazine , More

haldol 20 mg im

Share Email Print Feedback Close. Take this medication by mouth with or without food, or as directed by your doctor. For an initial approximation of the total daily dose required, the parenteral dose administered in the preceding 24 hours may be used.

haldol 20 mg im

Severe neurotoxicity manifesting as rigidity or inability to walk or talk may occur in patients with thyrotoxicosis also receiving antipsychotics. It can decrease negative thoughts and hallucinations. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown. Given that antagonism of D 2 receptors is more beneficial on the positive haldol 20 mg im of schizophrenia and antagonism of 5-HT 2 receptors on one cycle of steroids only negative km, this haldol 20 mg im underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis. The concentration of haloperidol in brain tissue is about fold higher compared to blood levels. Chlorprothixene Clopenthixol Flupentixol Tiotixene thiothixene Zuclopenthixol. Parenteral formulations are not recommended for use in children.