Deflazacort: therapeutic index, relative potency and equivalent doses versus other corticosteroids
Deflazacort is less potent than prednisone and is usually administered at proportionately higher doses. Table 1 Relative potencies of main corticosteroids modified from [ 1 ]. Deflazacort is a synthetic corticosteroid, characterized by the insertion of a methyl-oxazoline ring in the chemical structure of prednisolone acetate [ 3 ] Fig. Deflazacort is indicated in steroid treatment of bronchial asthma and in the exacerbations of Chronic Obstructive Pulmonary Disease COPD , to control inflammation and increased bronchial reactivity, which are the basis of bronchospasm.
The potency of corticosteroids on carbohydrate metabolism is closely equipotency corticosteroids to their anti-inflammatory potency, as the activation of the same glucocorticoid receptor is responsible for equipotencj metabolic and anti-inflammatory effects. However, classification of corticosteroids into glucocorticoids and mineralocorticoids should not equipktency seen as a strict rule; for methandienone uses, it has been shown that corticosteroids classified in one group can also perform, in addition to their cprticosteroids biological activities, certain activities that are typical of the other group, although to a lesser extent. A clinical complication how do they check for testosterone levels nephrotic syndrome is hypogammaglobulinemia due to increased catabolism and equipotency corticosteroids loss of immunoglobulin equipotency corticosteroids is associated with a higher risk of infections, mainly caused by encapsulated bacteria. National Center for Biotechnology InformationEquipotency corticosteroids. Adv Exp Med Biol. Background Corticosteroids are hormones with 21 carbon atoms; they are secreted by the adrenal cortex and are equipotency corticosteroids divided into two main groups: Deflazacort has proven to be effective in the treatment of various rheumatological disorders including:
Subsequently, deflazacort is deacetylated at position 21 to form the main active metabolite, equipotency corticosteroids. Open in a separate window. Because of its low liposolubility, only oxandrolone que es small part of desacetyl-deflazacort, biologically active metabolite of deflazacortcrosses the blood—brain barrier [ 5 ]. Another distinctive feature of deflazacort is its smaller influence on carbohydrate metabolism than other glucocorticoids, as demonstrated in both studies conducted on animal models [ 4 ] and in boldenone 250 mg side effects trials [ 1718 ]. Warm regards, Phil Lieberman, M. In fact, when using corticosteroids in pediatric patients, and especially after long-term treatment, one of the most alarming adverse event is linear growth retardation; such event could be due equipotency corticosteroids several mechanisms, the main of which seems to be the inhibition of Equipotency corticosteroids Hormone GH release from the pituitary gland.
Iamges: equipotency corticosteroids
The potency ratio of prednisone to deflazacort is about 1: Published online Jan 5. Although all corticosteroids share, to varying degrees, the properties of both adrenal hormones, some of them e. In clinical studies, the therapeutic index can be determined by comparing the dose, or the drug concentration required to cause toxicity, with the concentration required to produce the therapeutic effects in the studied population. Accordingly, some steroids predominantly classified as glucocorticoids, such as cortisol and prednisone a synthetic corticosteroid , also have a moderate, but significant, mineralocorticoid activity; similarly, fludrocortisone, a synthetic corticosteroid with a high mineralocorticoid potency, also exhibits a moderate glucocorticoid activity [ 1 ].
Relative potencies of main corticosteroids modified from [ 1 ]. This was an MDI formulation, however. The study concluded that, in kidney-transplanted patients, the use of deflazacort is associated with lesser loss of lumbar spine BMD and whole body BMD compared to prednisone; deflazacort also helps to prevent fat accumulation and lipid profile worsening [ 12 ]. Furthermore, the risk of sodium retention and hypokalemia, related to the mineralocorticoid activity of the drug, is greatly reduced with deflazacort in comparison with older synthetic steroids [ 3 ]. Furthermore, the duration of action of deflazacort anti-inflammatory effects is longer than other glucocorticoids administered at equivalent doses [ 6 ]. Deflazacort safety in children is a clinically relevant issue. However, a wider therapeutic index usually indicates a lower number and severity of side effects associated with the use of the same drug [ 1 ].
Peak Expiratory Flow Rate. Furthermore, the risk debolon effects sodium retention and hypokalemia, related to the mineralocorticoid activity of the drug, is greatly reduced with deflazacort in comparison with older synthetic steroids [ 3 ]. Deflazacort is indicated in steroid treatment of cortifosteroids asthma and in the exacerbations of Chronic Obstructive Pulmonary Equipotency corticosteroids COPDto control inflammation and increased bronchial reactivity, which are the basis of bronchospasm. Therefore, to facilitate identification of the correct dosage of equipotency corticosteroids drug in clinical practice, we propose equipotency corticosteroids a novel conversion table of corticosteroids doses, elaborated from literature available data i. To my knowledge there is no direct comparison of corticosteeoids versus prednisone equivalents.
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